Tag: timur

http://repository.uhamka.ac.id/359/

EFFECT OF INCREASING CETOSTEARYL ALCOHOL CONCENTRATION AS
THICKENING AGENT ON PHYSICAL STABILITY SCALPS NONI FRUIT
(Morinda citrifolia L.) EXTRACT LOTION

YATI, KORI

Noni fruits contain scopoletin. It known as inhibiting agent for Pityrosporum ovale
growing, the dandruff floral factor. To get the optimum effect, the 96% ethanol extract
of noni fruit (Morinda citrifolia.L) formulated into scalp lotion with cetostearyl
alcohol as a thickening agent. This research aimed at knowing the effect of
increasing cetostearyl alcohol concentration as thickening agent on physical stability
of the scalp lotion 96% ethanol extract of noni fruit. Firs step of research was made
noni fruit juice, followed by freeze drying process untill powder of noni juice formed.
Second step the powder was extracted by maceration method followed by vacuum
evavorated it to obtain viscous noni fruit extract. Scalp lotion made into 4 formulas
were: F1 (0.5%), F2 (1%), F3 (1.5%), F4 (2%). Each formula was evaluated every
week for 6 weeks in room temperature (± 25°C) for organoleptic, homogeneity,
emulsion type, pH, viscosity, density and separation phase test. The viscosity data
were analyzed by a theoretical approach and one-way ANOVA. Significant value
obtained of ANOVA p<0.05 means that there are significant differences in each formula, so it followed by Tukey HSD test. Based on analyzed of all data, it can be concluded that increasing concentrations of cetostearyl alcohol can increase the physical stability of scalp noni fruit extract lotion. Silahkan Download disini !

http://repository.uhamka.ac.id/360/

THE EFFECTIVENESS OF INFORMATION TECHNOLOGY
SYSTEMS OF E- LEARNING

Hamid Al Jufri, Jufri

This study aims to generate the effectiveness of information technology system of elearning
in order to improve the quality of learning. This research is motivated by the
vision and mission of UHAMKA. E-Learning is potential to make the learning
process more effective because either students or teachers are significantly benefited
in terms of place, flexibility, and enable learning activities anytime, anywhere, and
can be repeated. It is more efficient so that the productivity of activities is more.
Besides, it saves the cost of education, especially for students outside the city. In the
e-learning, it is not required additional specific software on the computer, as long as
the computer is equipped with an Internet connection.
Supporting theory used in this study are: theories about the effectiveness of the
information technology system of e-learning as proposed by Iivary (2005), Reymond
Mc Leod (2007), David Garvin, Jayce Rowe, Ralph Neal, (2000), Liu , Arnett (2000),
Molla, Lickers (2001), Glossary (2001), Vaughan Waller (2001), Kamarga (2002).
This research was conducted by the research approach of multivariate statistical
methods dependencies of Structural Equation Model (SEM). This research was
conducted by using quantitative data and positivism approaches. The data collection
was used survey techniques in the form of questionnaires. The population of this
research is the students of Master of Education Administration, University of
Muhammadiyah PROF. DR. HAMKA, total of 1117 people, and 102 people as
sample which consisted of 45 females and 57 males.
The results showed that the effectiveness of the information technology system of elearning
significantly helps students in learning and acquiring learning outcomes
higher (P> 0.95). E-Learning is able to improve the effectiveness of performance of
faculty and students because of the utilization of space, time, cost, and energy was
more efficient. Therefore, e-learning based model is effective to improve the quality
of teaching and learning

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http://repository.uhamka.ac.id/345/

KEMUHAMMADIYAHAN UNTUK PERGURUAN TINGGI

Muhammad Dwi Fajri, Dwi Fajri

Dalam Ensiklopedi Islam Indonesia tajdid diformulasikan sebagai
upaya atau aktivitas untuk merubah kehidupan umat dari keadaan yang
sedang berlangsung kepada keadaan baru yang hendak diwujudkan;
ia juga mengandung arti bahwa upaya itu adalah demi kemaslahatan
hidup mereka (baik di dunia maupun di akhirat), dikehendaki oleh
Islam, sejalan dengan cita-citanya, atau minimal berada dalam garis-
garis yang tidak melanggar ajaran dasar yang disepakati oleh para ulama

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TECHNICAL COEFFICIENTS AND TRADE COEFFICIENTS IN SOUTH KOREAN AND IN JAPANESE ECONOMIES: ARE THEY THE SAME?

Muchdie, Muchdie

This paper compared technical coefficients and trade coefficients in South Korean economy to those in Japanese economy
based on 30-sector classification of world input-output tables of the year of 2000, 2005 and 2010. The results showed that South Korean
economy had higher technical coefficients than that of Japanese economy, but statistically they were not significant. South Korean
economy used more input to produce output compared to that of Japanese economy. Technical index of South Korean economy was
lower than that of Japanese economy, but statistically it was not significant. Based on trade coefficients, this study showed that South
Korean economy had lower domestic component than Japanese economy did. This difference was statistically significant. Japanese
economy, technically, worked more efficiently; and Japanese economy used more domestic input. This paper also revealed that technical
index had a positive correlation with domestic component.

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ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD
SPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS
APPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

Supandi, Supandi

Objective: To analyze and validate 6-mercaptopurine (6-MP) and 6-methylmercaptopurine (6-MMP) in dried blood spots (DBS) using liquid
chromatography-tandem mass spectrometry (LC/MS-MS).
Methods: Bio-sampling dried blood spot with DBS-CAMAG® paper diameter of 8 mm and extracted with acetonitrile-methanol (1:3) containing
internal standard 5-fluorouracil (5-FU). Separation was performed with C18 column Acquity® 1.7 μm (2.1 mm × 100 mm), with a mobile phase mixture
of 0.1% formic acid in water 0.1% formic acid in acetonitrile with gradient elution and flow rate 0.2 ml/min. Mass detection was Waters Xevo TQD
with positive electrospray ionization (ESI) for 6-MP, 6-MMP and negative ESI for 5-FU in multiple reaction monitoring modes. The ions of 6-MP was
detected at m/z 153.09->119.09, 6-MMP at m/z 167.17->126.03, and 5-FU at m/z 129.15->42.05.
Results: This method fulfill the requirements of selectivity, linearity, lower limit of quantification, accuracy, precision, carry-over, matrix effects,
and stability which refers to the european medicines agency (EMEA) guidelines. The linearity of 0.99 was 26-1000 ng/mL for 6-MP and 6-MMP,
respectively. The validated method was applied to two childhood ALL maintenance phase. Retrieved 6-MP levels of 10.37 pmol/8×108 erythrocytes,
respectively. The levels of 6-MMP gained 16.59 pmol/8×108 erythrocytes, respectively.
Conclusion: The developed LC/MS-MS method is valid to analysis 6-MP and 6-MMP in DBS simultaneous in vitro according to EMEA guidelines. The
method was successfully applied to authentic capillary blood samples from two childhood patients with ALL in the maintenance phase.
Keywords: 6-mercaptopurine, 6-methylmercaptopurine, Dried blood spots, Acute lymphoblastic leukemia.

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SECTOR AND SPATIAL-SPECIFIC MULTIPLIERS IN NUSA
TENGGARA ISLANDS’ ECONOMY: AN INTER-ISLAND INPUTOUTPUT
ANALYSIS

Muchdie, Muchdie

This paper aimed to provide the results of analysis on total and flow-on multipliers, sectorspecific,
and spatial-specific multipliers in Nusa Tenggara Islands’ economy, mainly for
planning and evaluation purposes. These Islands consist of three provinces: Bali, West Nusa
Tenggara and East Nusa Tenggara. The model employed was Inter-Island Input-Output Model
(IIIOM) developed using new hybrid procedures with special attention on Island economy. Data
used for model were updated Indonesian data for the year of 2015. The results show that firstly,
the important sectors of Nusa Tenggara Island economy could be based on total multipliers and
flow-on effects of output, income and employment. Secondly, important economic sectors could
be based on sector-specific multipliers effects; multipliers that occurred in own sector and other
sectors. Thirdly, important economic sectors could be based on spatial-specific multipliers;
multipliers that occurred both in own region and other regions. Fourthly, important economic
sectors could be based on spatial distribution of flow-on; flow-on effects that occurred in own
region as well as in other regions.

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PROSFEKTIF METODE SAMPEL DARAH KERING DALAM BIOANALISIS

Supandi, Supandi

Biosampling of dried blood spot method became lately very interested in bioanalysis, some of the advantages given in this method compared to conventional venous canulla (venipuncture); less invasive making it more pleasant for the patient or subject, requires small volume, requires simple transportation process and storage did not need special equipment, suod stabilizes analit and reduces risk of infection. The method of dried blood spot is done by invasive light on the finger or heel prick and then spike on filter paper and dried at room temperature or under nitrogen flow with controlled humidity and stored in bag with desiccant packages, than it analyzed using validation bioanalyzing method. Dried blood spot method can be applied on bioanalysis test for pharmacokinetic, toksikokinetic , epidemiologic and Teurapeutic drug monitoring.

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http://repository.uhamka.ac.id/363/

TECHNICAL AND TRADE COEFFICIENTS IN INDONESIAN AND
AUSTRALIAN ECONOMIES: A COMPARISON

Muchdie, Muchdie

This paper compared technical coefficients and trade coefficients in Indonesian economy to those in Australian
economy, based on 30-sector classication
of world input-output tables of the year of 2000, 2005 and 2010. The
results showed that Indonesian economy had lower technical coefficient than that of Australian economy, but statistically it was not
signicant.
Indonesian economy used less input to produce output compared to that of Australian economy. Indonesian technical index, an
inverse of technical coefficient, was higher than that of Australian and again it was not statistically signicant.
Based on trade coefficients,
this study showed that Australian economy had higher domestic component than Indonesian economy did. This difference was statistically
signicant.
Indonesian economy, technically, worked more efficiently; but Australian economy used more domestic input. This paper also
revealed that technical coefficient had a positive correlation with import component and technical index had positive correlation with
domestic component

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SIMULTANEOUS ANALYTICAL METHOD DEVELOPMENT OF 6-MERCAPTO¬PURINE AND 6-METHYLMERCAPTOPURINE IN PLASMA BY HIGH PERFOR¬MANCE LIQUID CHROMATOGRAPHY-PHOTODIODE ARRAY

Supandi, Supandi

Objective: 6-Mercaptopurin is antineoplastic drug that is included in antimetabolite
group and is used in acute lymphoblastic leukemia medication. 6-Mercaptopurin
is inactive pro-drug that will be metabolized into metabolites. One
of its metabolites is 6-methylmercaptopurine. This study is aimed to optimize
the analytical conditions and perform validation for the analysis of 6-mercaptopurine
and 6-methylmercaptopurine in plasma. Method: Separation was performed
using Waters 2996 HPLC, C18 SunfireTM column (5μm, 250 x 4.6 mm)
with the mobile phase containing water-methanol-acetonitrile with gradient
elution, and detected at 303 nm. 5-Fluorouracil was used as internal standard.
Plasma extraction was done by liquid-liquid extraction using dichloromethane.
Result: The method was linear at concentration range of 2.0 – 200.0 ng/mL
with r > 0.9991 for 6-mercaptopurine and 20 – 2000 ng/mL with r > 0.9993 for
6-methylmercaptopurine. Accuracy and precision within-run and between-run
fulfill the acceptance criteria with % RE and relative standard deviation (%
RSD) ≤ 20% (LLOQ) and ≤ 15% (QC samples). 6-Mercaptopurine and 6-methylmercaptopurine
was stable in plasma at least for 21 days when stored at -20ºC.
Conclusion: The bio-analytical method was sensitive, selective and all the parameters
fulfilled the acceptance criteria of the EMA Bio-analytical Method
Validation Guideline, 2011.

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CHANGES IN MUSLIM DIVORCE MEDIATION IN INDONESIA: A CASE STUDY OF THE
YOGYAKARTA RELIGIOUS COURT

Rita Pranawati, Rita

This article explores the current mediation of Muslim divorce in the Yogyakarta religious court
in Indonesia. In 2008 the Indonesian Supreme Court introduced a regulation requiring that all
courts should adopt a uniform mediation procedure. This study analyses changes in the
mediation process in Yogyakarta since Nakamura conducted the Muslim divorce research in
the 1970s. The research shows that the current mediation process, which is still in a transition
stage, is a more systematic and formal procedure. This change is more appropriate for
educated and middle class clients but not necessarily for the poor, especially poor women.
However, the current system is more concerned about the rights of women and children. The
article considers the implications of the secularisation of mediation in Muslim divorce such as
the change of the administrative supervision of the Religious Court from the Ministry of
Religious Affairs to general court practice under the jurisdiction of the Supreme Court where
previously the judge did not have more roles than the religious leaders. There is also some
tension between the new mediation system and Islamic mediation of the kind practised by
BP4.The certificate mediator requirement has also eliminated the BP4 volunteers who are not
eligible. The article concludes that a specific model of Muslim divorce mediation with suitable
success indicators needs to be developed. It should also involve BP4 to recognise its
experience in this area

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