Tag: ciracas.id

Hannah Natasha Andjani, Natasha

Replacement of synthetic pesticide with natural pesticide is highly demanding because it is more
environmentally friendly. Tobacco is majorly exploited for cigarettes production. Therefore, it needs to be developed for
other alternative products, one of which is insecticide due to nicotine content and other toxic compounds. This research
aimed to determine the effectiveness of tobacco as an insecticide for Galleria mellonella and Gryllus bimaculatus. The
raw material used in this study was the leaf extract of Nicotiana tabacum L., var. Virginia that was obtained by Ethanolic
Heat Reflux Extraction (EHRE) technique. After testing on the insects, LC50 values were 36.6 mg/ml for Galleria
mellonella and 38.5 mg/ml for Gryllus bimaculatus.

http://repository.uhamka.ac.id/831/1/Hanna.pdf

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http://repository.uhamka.ac.id/816/

Inding, Gusmayadi

Lozenges require the tablet hardness of 7-14 Kgf to be a suitable binder. Gelatine can be used to meet the
requirement as it creates granules with bad flow time. PVP produces granules with better flow time but it
takes a large quantity to reach the lozenges hardness desired. This study aimed to determine the effect of the
concentration ratio of gelatine and PVP as binders on the physical properties of red-ginger extract lozenges.
Lozenges made employing the wet granulation method following the ratio of gelatine and PVP of 1:1, 1:2,
1:3, 1:4 and 1:5. The hardness test results of the formula 1 to 5 are 9, 14, 16, 13 and 12 Kgf respectively and
the friability test results were 0,4%, 0,7%, 0,2%, 0,3% and 0,6% accordingly. The combination of gelatine
and PVP as binders provide a significant difference in the hardness and friability of the tablets.

http://repository.uhamka.ac.id/816/1/MICH-PhD_2018_26.pdf

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Nurul Hidayat, Nurul

Benzoin absolute essential oil is a high-value oleoresin derived from the dried sap of the Styrax benzoin tree.
One type of Styrax benzoin traded in Indonesia is black Sumatran incense. Reflux extraction method with ethanol is used
to gain the benzoin absolute essential oil. The purpose of this study is to investigate the antioxidant activity of benzoin
absolute essential oil produced using ethanol reflux extraction. Antioxidant test showed that black Sumatran Incense has
active antioxidant properties with IC50 value is 90.03; the antioxidant activity shows potential alternative utilization of
this essential oil industry, especially those derived from incense resin and its derivatives.

http://repository.uhamka.ac.id/832/1/Nurul.pdf

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MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR KIMIA DASAR DENGAN METODE PEMBELAJARAN DISCOVERY PADA MAHASISWA SEMESTER SATU DI FFS UHAMKA

Wati Sukmawati, Wati

Upaya meningkatkan motivasi dan prestasi belajar mahasiswa melalui metode pembelajaran discovery kimia dasar semester satu Fakultas Farmasi dan Sains Prodi Farmasi Tahun 2018. Latar belakang masalah penelitian ini adalah berdasarkan observasi awal prosentase hasil belajar mahasiswa masih rendah dapat dilihat dari hasil ujian dari beberapa kelas. Salah satu upaya yang dapat dilakukan untuk meningkatkan prestasi belajar mahasiswa adalah dengan menerapkan Metode Pembelajaran discovery dengan kerja kelompok. Tujuan dari penelitian ini adalah untuk meningkatkan prestasi belajar mahasiswa melalui Metode Pembelajaran interaktif dengan kerja kelompok di FFS UHAMKA. Penelitian ini merupakan Penelitian Tindakan Kelas yang terdiri dari dua siklus kegiatan. Dengan menggunakan metode Penelitian Tindakan Kelas dengan mencakup kegiatan: 1) Perencanaan, 2) Pelaksanaan, 3) Observasi dan 4) Refleksi. Subyek penelitian adalah mahasiswa semester I. Pengambilan data dilakukan dengan metode tes, wawancara, dokumentasi dan observasi. Hasil penelitian menunjukkan bahwa 1) Kinerja belajar mahasiswa meningkat setelah melaksanakan proses pembelajaran kimia dasar menggunakan Metode Pembelajaran interaktif. 2) Prestasi belajar mahasiswa meningkat setelah mengalami pembelajaran interaktif dengan tugas kelompok. Pada siklus I prestasi yang mencapai ketuntasan sebesar 75% dan pada siklus II sebesar 100%. Dan dari siklus I ke siklus II mengalami peningkatan sebesar 25%.

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http://repository.uhamka.ac.id/796/1/84-Article%20Text-177-1-10-20190208.pdf

Indonesian Mirabilis jalapa Linn. : A Pharmacognostical and
Preliminary Phytochemical Investigations

Mirabilis jalapa Linn. is an important medicinal plant and used extensively by the people from different
countries for the treatment of several disorders. The plant was the raw material for the herb-drug product, so some
parameters identified were needed to ensure the safety, quality and efficacy of the product. Objective: The aim of this
study was to undertake pharmacognostical studies to fulfill the work required for the identification the M. jalapa plant,
which is collected from the Bogor area, Indonesia. Methods: Macroscopic and microscopic evaluation, fluorescence
standards, phytochemical screening and physicochemical parameters were carried out on the above plant. Results: The
parameters values of total ash, water soluble and acid insoluble ash were obtained 11.81, 5.06 and 0.41%, respectively.
Moisture content, alcohol, water and ether soluble extractive were found to be 12.41, 11.02, 18.63 and 7.17% respectively.
The results of preliminary phytochemical analysis of aqueous ethanolic extract of this drug were positive for alkaloids,
tannins, flavonoids, steroid, triterpenoids, saponin, phenols, glycosides and carbohydrate. Thin layer chromatography
(TLC) of alcoholic, chloroform and aqueous extracts showed 9, 7 and 4 spots respectively. Conclusion: The present
study on botanical pharmacognosy and TLC profile of this plant above thus provides useful information for correct identification
and quality control parameters for the crude drugs, and also will be useful in making monograph of the plant.

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http://repository.uhamka.ac.id/797/1/10.5530pj.2017.5.108.pdf

The Potency of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)
Subfraction with Ethanol 70% as an Antihyperuricemic Agent

Hyperuricemia is an abnormally high level of uric acid in a blood. Binahong leaves (Anredera cordifolia
(Ten.) Steenis) is one of the plants traditionally used as an antihyperuricemic remedy. This study aims to
determine the ethanol 70% subfraction activity of binahong leaves on the uric acid level of male white mice.
Antihyperuricemia assay was conducted for 36 days by dividing 24 mice into six groups. There are normal
control who was given standard feed and Na CMC 0.5%, positive control was given purine and allopurinol
0.8 mg/20 g BW and the assay group was given a purine feed and binahong leaves subfraction SF 3 with a
dose of 1.83 mg/20gBW, 3.60 mg/20gBW, and 5.40 mg/20gBW. Blood sampling was conducted by orbital
sinus after 2 hours from induction of potassium oxonate. Blood sampling was measured with an enzymatic
method using a clinical spectrophotometer. The result showed that the third dose had no significant
difference to the positive control with a percentage of decrease of 56.6%. The conclusion is that binahong
leaves subfraction has the same activity as an antihyperuricemic agent with allopurinol at dose 5.40
mg/20gBW.

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http://repository.uhamka.ac.id/798/1/MICH-PhD_2018_25.pdf

Pharmacognostical Studies and Determination of Total
Flavonoids of Paitan (Tithonia diversifolia (Hemsl.) A. Gray

Tithonia diversifolia (Hemsl.) A. Gray is one of the plants used in traditional medicine and
belongs to Compositae family. In different parts of Indonesia, it is commonly known as “paitan
and kembang bulan”. The study provides an early description of Tithonia diversifolia (Hemsl.)
A. Gray) and complete the monographs data extract. This plant prospects to the main source
of the raw material for the herb-drug product and some parameters identified were needed to
ensure the safety, quality and efficacy of the product. The present study is to evaluate macrosand
microscopic characteristic of the Indonesian plant and its quality parameter including
fluorescence, physicochemical characteristics and phytochemical screening. Moisture content,
ethanol and water-soluble extract was determined, and were discovered to be 11,27%, 4,73%
and 18,01%. Total ash value and acid insoluble ash value were determined which was 10.29
and 0.72 % respectively. Phytochemical screening of aqueous ethanol extract of Tithonia
diversifolia showed the presence of alkaloids, flavonoids, tannins, saponins and triterpenoids.
The result showed that average content of flavonoid total is 69.1653 mg QE/g extract.

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http://repository.uhamka.ac.id/799/1/PJ-11-6-318.pdf

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability

As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.

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http://repository.uhamka.ac.id/804/1/9138-25053-2-PB.pdf

Tablet Kunyah Ekstrak Daun Jambu Biji (Psidium Guajava L.) Dengan Amilum Sukun Sebagai Pengikat

Amilum sukun dapat digunakan sebagai pengikat pada tablet kunyah karena terdiri dari amilosa dan amilopektin karena dapat meningkatkan daya kohesifitas dan membentuk ikatan yang baik pada serbuk. Ekstrak daun jambu biji (Psidium guajava L.) mampu membunuh pertumbuhan bakteri Streptococcus mutans sehingga dapat berfungsi untuk mencegah karies gigi. Penelitian ini bertujuan untuk melihat pengaruh peningkatan amilum sukun terhadap karakteristik fisik tablet kunyah ekstrak daun jambu biji. Tablet kunyah ini dibuat dalam 4 formula yang masing – masing formula terdiri dari mucilago amilum sukun 10 %, 13%, 16% dan 19%. Amilum sukun sebagai pengikat didapat dari buah sukun yang hampir matang dan dihancurkan lalu direndam hingga terjadi pemisahan antara air rendaman dan amilum, selanjutnya amilum dikeringkan dan dibuat mucilago untuk ditambahkan ke dalam formula. Hasil karakteristik amilum, serbuk yang didapat benar adalah amilum sukun. Granul yang dihasilkan dievaluasi kemampuan mengalir dan distribusi ukuran partikel. Selanjutnya, granul dibuat menjadi tablet kunyah. Hasil evaluasi tablet kunyah menunjukkan bahwa peningkatan konsentrasi mucilago amilum sukun mampu meningkatkan kekerasan dan menurunkan keregasan dari tablet kunyah.

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http://repository.uhamka.ac.id/803/1/87-Article%20Text-141-1-10-20190614.pdf

VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACT EFFERVESCENT TABLET

Citric acid is an acid source in effervescent tablet it reacts rapidly, can increase dissolving time. In this research, extract was made into effervescent tablet. The research aimed at knowing increased concentration of citric acid as acid source can improve the physical characteristic of effervescent tablet. Pericarp mangosteen dry extracts macerated by water, and powder made by spray dryer. Dry extract was made into 5 formulas effervescent tablet with the different concentrations of citric acid, 15%, 20%, 25%, 30% and 35% as acid sources. The tablets were evaluated included organoleptic evaluation, weight uniformity, size uniformity, hardness, friability, and dissolving times. The result of dissolving time are 10,50±0,57 minutes, 4,52±1,04 minutes, 3,32±0,13 minutes, 3,13±0,14 minutes and 3,42±0,14 minutes. By one way ANOVA test dissolving time data showed differences each other 95% in signifigancies. It can be concluded that increasing of citric acid gave effect on dissolving time, and the citric acid with concentration of 35% can reduce dissolving time of the pericarp mangosteen (Garcinia mangostana L.) dry extract effervescent tablets.

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http://repository.uhamka.ac.id/805/1/3321-73-6229-1-10-20190321.pdf